Can computer vision identify features invisible to the human eye that can assist in non-invasively identifying aneuploid embryos?

Aneuploidy is the most common explanation for implantation failure in top-quality blastocysts. Yet, top-quality blastocysts with unknown varying ploidies are often indistinguishable at the resolution of the human eye alone. There is a need for non-invasive techniques that detect bio-features in blastocysts, which are indicative of their ploidy status and likelihood of implantation success.

The objective of this study was to assess a unique feature identified only through computer vision that allows non-invasive differentiation between euploid and aneuploid embryos. Our data suggests that the application of computer vision methodology for non-invasive genetic profiling may be useful to striate embryos for clinical transfer and/or genetic testing.

It was concluded that aneuploid embryos were found to more frequently present a less-fluidic cytoplasmic texture in the early blastulation stage than euploid embryos; a difference detected using our proprietary non-invasive computer vision system, which can identify and reject these aneuploids during embryo evaluation.

Details about materials, methods, results, and impact are found in the poster below.

Research was conducted by Daniella Gilboa, MSc, CEO and Co-founder of AIVF, Prof. Daniel Seidman, CMO and Co-founder of AIVF, Ron Maor, CTO of AIVF, and two of the company’s esteemed scientific advisors, Gary Harton, PhD and Dr. Marcos Meseguer Escrivá.

Dr. Gary Harton is a leading researcher in the fields of preimplantation genetic testing including monogenetic diseases (PGT-M), structural chromosome rearrangements (PGT-SR), and aneuploidy (PGT-A), as well as assisted reproductive technologies (ART). Dr. Marcos Meseguer Escrivá is lab director of IVIRMA and Associate Professor at Valencia University’s Masters in Biotechnology program.

To view the poster click HERE